International Journal of Pharmaceutical Science Invention (IJPSI)
نویسندگان
چکیده
Since the introduction of the floroquinolones for clinical use in the late 1980s, they have been used successfully for a large number of clinical situations. The quinolones inhibit bacterial DNA replication by inhibiting DNA gyrase and topoisomerase IV. Careful clinical studies are needed to establish the efficacy of once daily use of fluoroquinolones, to determine that clinical efficacy is equivalent to multiple doses, and that once-daily dosing does not results in development of resistant bacteria. Single-dose therapy with quinolones would be an improvement in cost and patient compliance.
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